{"id":1114,"date":"2015-04-13T05:54:43","date_gmt":"2015-04-13T05:54:43","guid":{"rendered":"http:\/\/www.ahmadfanaei.com\/en\/?post_type=post&amp;p=1114"},"modified":"2015-04-13T05:54:43","modified_gmt":"2015-04-13T05:54:43","slug":"aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers","status":"publish","type":"post","link":"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/","title":{"rendered":"Aberrant methylation of Rap\u06f1Gap gene promoter in thyroid cancers"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/#Introduction\" >Introduction<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/#Methods\" >Methods<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/#Results\" >Results<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/#Conclusion\" >Conclusion<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Introduction\"><\/span>Introduction<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Thyroid carcinoma is the most common endocrine malignancy in worldwide. Hypermethylation of suppressor genes considered as the hallmark of cancers. Rap1Gap as a suppresser gene is implicated in the regulation of oncogenic pathways in thyroid carcinoma. The objective of this study was to examine the DNA methylation pattern of Rap1Gap gene in thyroid carcinoma.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Methods\"><\/span>Methods<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>We analyzed 95 thyroid tumor samples including normal thyroid (28 cases), benign nodules (29 cases), papillary thyroid cancer (PTC) (29 cases), follicular thyroid cancer (FTC) (6 cases) and Anaplastic thyroid cancer (ATC) (3 cases) from Erfan grand hospital, Tehran, Iran. Rap1Gap gene expression was assessed using SYBR Green Real-Time PCR. CpG24 Island within Rap1Gap promoter region was selected; DNA methylation pattern was examined using methylation specific PCR (MSP).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Results\"><\/span>Results<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>This study showed that Rap1Gap was frequently lost or downregulated in various types of tumors, particularly in the most invasive and aggressive forms of thyroid cancer. Downregulation could be related to promotor hypermethylation. DNA methylation was identified in 21% of normal tissues, 86% of benign nodules, 90% of differentiated tumors (PTC, FTC) and 100% of undifferentiated tumors (ATC).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>T<\/strong>he result of this study demonstrates that Rap1Gap is likely to serve as an important tumor suppresser gene in thyroid cells and its loss during aberrant methylation contributes to tumor progression and invasion.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"References\"><\/span>References<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ol>\n<li>Tetsuo Kondo, Tadao Nakazawa, Defu Ma, et al. Epigenetic silencing of TTF-1\/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19506552\">Lab Invest<\/a> 2009.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Faam%20B%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=25469237\">Faam B<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Ghaffari%20MA%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=25469237\">Ghaffari MA<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Ghadiri%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=25469237\">Ghadiri A<\/a>, et al. Epigenetic modifications in human thyroid cancers. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25469237\">Biomed Rep<\/a>, 2015.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Introduction Thyroid carcinoma is the most common endocrine malignancy in worldwide. Hypermethylation of suppressor genes &#8230; <a class=\"cz_readmore\" href=\"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/\"><i class=\"far fa-square-plus\" aria-hidden=\"true\"><\/i><span>\u0627\u062f\u0627\u0645\u0647 \u0645\u0637\u0644\u0628<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":1115,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[],"class_list":["post-1114","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.4 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Aberrant methylation of Rap1Gap gene promoter in thyroid cancers - Dr.Ahmad Fanaei<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ahmadfanaei.com\/en\/aberrant-methylation-of-rap1gap-gene-promoter-in-thyroid-cancers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aberrant methylation of Rap1Gap gene promoter in thyroid cancers\" \/>\n<meta property=\"og:description\" content=\"Introduction Thyroid carcinoma is the most common endocrine malignancy in worldwide. 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